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Shalender Bhasin, MD
Brigham and Women’s Hospital,
Harvard Medical School

PI and Director, Boston Claude D. Pepper Older Americans Independence Center
Professor of Medicine Harvard Medical School
Director, Center for Clinical Investigation
Director, Research Program in Men’s Health: Aging and Metabolism

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Dr. Bhasin is an internationally recognized expert in human aging, clinical trials of function promoting therapies for older adults, functional decline in aging, and testosterone biology. He chaired the Endocrine Society’s Expert Panel for the development of Guidelines for Testosterone Therapy. He is a translational researcher, with over 250 peer-reviewed manuscripts, 130 reviews and book chapters. Dr. Bhasin’s research has led to new applications of androgens and selective androgen receptor modulators. His pioneering research in androgen biology and anabolic therapies for aging-associated sarcopenia has been supported by several NIH-funded grants.

He received his MD from the All India Institute of Medical Sciences in New Delhi, India, residency training at Northwestern University Medical School and fellowship training in Endocrinology and Nutrition at Harbor-UCLA Medical Center in Los Angeles, CA.

Dr. Bhasin has been the recipient of numerous teaching and research awards. He has served as: Associate Editor of the JCEM; Chair of the Clinical Guidelines Committee of the Endocrine Society; Chair of the Clinical Guidelines Panel of the Endocrine Society for diagnosis and treatment of hypogonadism; and Chair of American Board of Internal Medicine Endocrinology and Metabolism Board. He has been selected as one of the Best Doctors in America by Castle Connolly and by Boston Magazine. He is the recipient of the 2015 Outstanding Clinical Investigator Award of the Endocrine Society.

Roger Fielding, PhD
Tufts University

Associate Director, Boston Claude D. Pepper Older Americans Independence Center
Professor of Nutrition at the Friedman School of Nutrition Science and Policy
Professor of Medicine at Tufts University School of Medicine
Director and Senior Scientist of the Nutrition, Exercise Physiology, and Sarcopenia (NEPS) Laboratory
Senior Scientist Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University

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Dr. Fielding is an internationally known researcher who studies the underlying mechanisms contributing to the age-associated decline in skeletal muscle mass, the resultant impact on function, and the potential role of exercise and physical activity on attenuating this process. Dr. Fielding has a strong record of NIH funding and oversaw the development of the interventions for the LIFE (Lifestyle Interventions for Elders) Pilot study and served as the Chair of the LIFE Intervention and Operations Committee. He also is a co-investigator and chair of the Body Composition Analysis committee for the NIA-funded “Calerie” trial.

Alan M. Jette, PT, PhD, F.A.P.T.A.
Boston University’s School of Public Health 

Professor of Health Policy & Management at Boston University’s School of Public Health
Director of Boston University’s Health & Disability Research Institute
Research Director for the New England Regional Spinal Cord Injury Center at Boston University Medical Center
Director of the Boston University Post Doctoral Research Fellowship in Rehabilitation Outcomes and Effectiveness Research

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Dr. Jette’s is an internationally recognized expert in the measurement of function and disability.  He has developed numerous instruments that assess function and disability and has published numerous articles on these topics in the rehabilitation, geriatrics, and public health literature.  Dr. Jette’s current research interests include the measurement, epidemiology, and prevention of disability, and the development and dissemination of contemporary outcome measurement instruments to evaluate the quality of health care.

Edward Marcantonio, MD,
Beth Israel Deaconess Hospital,
Harvard Medical School

Professor of Medicine, Harvard Medical School
Section Chief for Research in the Division of General Medicine and Primary Care

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Dr. Marcantonio’s is an internationally recognized expert and clinical investigator in the area of delirium. He has conducted a series of observational and interventional studies designed to improve delirium identification, target individuals at risk, identify modifiable risk factors, and test intervention strategies to reduce the incidence, severity and duration of delirium. He currently lead three NIH-funded studies in delirium research, including the Biomarker Discovery for Delirium project within the first NIH-funded program project in the field of delirium research.

Lewis A. Lipsitz, MD
Beth Israel Hospital,
Harvard Medical School

Associate Director Claude D. Pepper Older Americans Independence Center
Professor of Medicine Harvard Medical School
Chief of Gerontology
Director, Institute for Aging Research
Vice President for Academic Medicine, Hebrew Senior Life

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Dr. Lipsitz was one of the first geriatricians to be trained in the Harvard Geriatric Fellowship Program. He subsequently became a National Institute on Aging Academic (K23) Awardee, with Hebrew SeniorLife (formerly the Hebrew Rehabilitation Center for Aged) as his primary clinical and research site. As a fellow, he began a systematic series of epidemiologic and physiologic studies evaluating syncope and abnormal blood pressure regulation, discovered postprandial hypotension in the elderly, and subsequently acquired funding for his studies through an NIA-funded Program Project, which he directed for 20 years. In this capacity he provided on-site management and established strong working relationships with project directors from multiple Harvard-affiliated institutions. This program project supported the prospective, observational MOBILIZE Boston Study, which has elucidated numerous novel risk factors for falls over the past 10 years. Dr. Lipsitz’s research has been quite productive, resulting in 250 original articles in peer-reviewed journals, many of which involve clinical trials and translational research.

During his career, Dr. Lipsitz has received continuous NIA funding for his research, directed an Older Americans Independence Center, led a T32 training program and the Hartford Center of Excellence in Geriatric Medicine at Harvard Medical School (HMS), and acquired two D.W. Reynolds Grants for geriatric education at HMS. He has mentored 34 successful postdoctoral trainees, including 2 Beeson Scholars and 4 T32 trainees, and received the prestigious “William Silen Lifetime Achievement” award for mentoring. His research into various function promoting therapies, access to Harvard-wide resources, academic leadership experience, skills in mentoring, and familiarity with NIA Center Grants and Boston’s academic geriatric community all make him ideally suited to lead the Boston OAIC and its Research Education Component.

Douglas P. Kiel, MD,
Hebrew Senior Life,
Harvard Medical School

Professor of Medicine, Harvard Medical School
Director Musculoskeletal Research Center Institute for Aging Research, Hebrew Senior Life
Associate Member Broad Institute of Harvard and MIT

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Dr. Kiel’s research focuses on the epidemiology of osteoporosis and related fractures, including lifestyle factors, biomarkers, and genetic factors.  He is also interested in sarcopenia and its consequences, including falls and disability.  He also has conducted multiple clinical trials targeting the musculoskeletal system.  He leads the Framingham Osteoporosis Study, and serves in leadership roles for many organizations including the NIH, American Society for Bone and Mineral Research, National Osteoporosis Foundation, and the Joint Commission.

Amy Wagers, PhD,
Joslin Diabetes Center,
Harvard University

Forst Family Professor of Stem Cell and Regenerative Biology, Harvard University
Director DERC/HSCI Flow Cytometry Core, Josilin Diabetes Center
Director HSCRB Flow Cytometry Core, Harvard University

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Dr. Wagers is an established investigator who has led a research laboratory studying the regenerative biology of aging for more than 10 years. She is also a Principal Faculty member of the Harvard Stem Cell Institute and serves on its Executive Committee. Dr. Wagers is a recipient of the Burroughs Wellcome Fund Career Award, the Beckman Foundation Young Investigator Award, the WM Keck Foundation Distinguished Young Scholar Award, and the NIH Director’s New Innovator Award. Her current research focuses on defining the factors and mechanisms that regulate the migration, expansion, and regenerative potential of adult blood-forming and muscle-forming stem cells.

She received her Ph.D. in Immunology and Microbial Pathogenesis from Northwestern University in 1999, and then worked as a postdoctoral fellow studying stem cell biology in the laboratory of Dr. Irving Weissman in the Department of Pathology at Stanford University School of Medicine.

Thomas Travison, PhD,
Hebrew Senior Life,
Harvard Medical School

Assistant Professor of Medicine
Director of Biostatistics Institute for Aging Research, Hebrew Senior Life
Co-Director, Program on Clinical Trials for IFAR

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Thomas Travison is Senior Scientist and Director of Biostatistics at the Hebrew SeniorLife Institute for Aging Research (IFAR), Assistant Professor of Medicine at Harvard Medical School. He co-directs the Interventional Studies in Aging Center at IFAR. Dr. Travison’s work has focused on the interface between the endocrinology of aging and functional decline, on multicomponent interventions for the prevention of loss of independence in aging, and on graphical data display. He was lead author on the development of the first assessments of clinical significance of androgen supplementation for improvement of physical function in frail men with mobility limitation, and of the durability of androgen insufficiency in community-dwelling men. He is lead biostatistician on the NIA / FNIH Sarcopenia Consortium, which addresses the influence of body mass and function on mobility limitation and downstream clinical endpoints. He leads the analytic team for the Endocrine Society / CDC / PATH multicohort derivation of age-specific sex steroid reference ranges in men, and has designed and analyzed numerous clinical trials of function-promoting interventions in older women and men. 

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Monty Montano, PhD,
Brigham and Women’s Hospital,
Harvard Medical School

Assistant Professor of Medicine
Director of Muscle and Aging Interventions, Brigham and Women’s Hospital
Scientific Director, Boston Claude D. Pepper Older Americans Independence Center

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Dr. Montano is a translational researcher in muscle healthspan, genetics of lifespan, biomarker discovery, and inflammation. Dr. Montano’s research in muscle regenerative biology, muscle fibrosis and inflammation and accelerated muscle aging in chronic infection and age-associated sarcopenia has been supported by NIH-funded grants. He has written several papers directly relevant to this proposal including a paper describing anabolic response in muscle from HIV patients with wasting (1), a study describing age differences in anabolic response based on serum profiling (2), a manuscript demonstrating accelerated muscle aging in the context of HIV infection (3) and decline in physical function in association with inflammation and chronic HIV infection (4). Dr. Montano also recently authored a book “Translational Biology in Medicine” (5) on the use of translational models to study biomedical disease, with a focus on aging.

Dr. Montano received his BA in biochemistry from U.C. Berkeley, his PhD in genetics from Stanford University and conducted his postdoctoral work at the Harvard School of Public Health.

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Ravi Jasuja, PhD,
Brigham and Women’s Hospital

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Small Animal Resource Core Leader Ravi Jasuja received his Bachelor’s degree in Technology from the Indian institute of Technology, Delhi , PhD from the University of Hawaii, Manoa with Dr. Randy Larsen and conducted his postdoctoral research with Dr. Shahid Khan (at Albert Einstein College  of Medicine)  and Dr. Frank Ferrone (at Drexel University). Dr. Jasuja is an Assistant Professor of Medicine in the Endocrinology section and the director of Metabolic Phenotyping Core. His research interests include: 1. Biophysical characterization of ligand-specific conformational dynamics in Androgen Receptor 2. Mechanisms of tissue-specific action of androgens on muscle, bone, prostate adipose tissue remodeling by circulating androgens in animal models and development  of Selective  Androgen Receptor Modulators.